Pub. Date : 2020
PMID : 32929377
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of miR-575 decreased tamoxifen sensitivity by targeting CDKN1B and BRCA1. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 2 | Furthermore, miR-575 expression was found to be upregulated in ER+ breast cancer cell with acquired tamoxifen resistance, whereas depletion of miR-575 partially re-sensitized these cells to tamoxifen by regulation of CDKN1B. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 3 | Conclusions: Our data reveal the ERalpha-miR-575-CDKN1B feedback loop in ER+ breast cancer, suggesting that miR-575 can be used as a prognostic biomarker in patients with ER+ breast cancer, as well as a predictor or a promising target for tamoxifen sensitivity. | Tamoxifen | cyclin dependent kinase inhibitor 1B | Homo sapiens |