Title : Inhibitory effect of anti-seizure medications on ionotropic glutamate receptors: special focus on AMPA receptor subunits.

Pub. Date : 2020 Nov

PMID : 32911258






1 Functional Relationships(s)
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1 The majority of other ASMs evaluated in this study did not show a direct inhibitory effect on almost any of the glutamate receptor functions examined up to 1 M. However, lamotrigine and carbamazepine inhibited hNR1/hNR2B function at IC50 values of 930,000 and 1,000,000 nM, respectively. Lamotrigine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens