Pub. Date : 2021 Apr 1
PMID : 32909036
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we used crystallography and NMR spectroscopy to demonstrate that negatively charged homogalacturonans (HG, linear polysaccharides of alpha(1 4)-linked-D-galacturonate (GalA)) bind to the galectin-3 carbohydrate recognition domain. | Carbohydrates | galectin 3 | Homo sapiens |
| 2 | The HG carboxylates at the C6 positions in GalA rings mandate that this saccharide bind galectin-3 in an unconventional, "topsy-turvy" orientation that is flipped by about 180o relative to that of the canonical beta-galactoside lactose. | Carbohydrates | galectin 3 | Homo sapiens |