Pub. Date : 2020 Sep 8
PMID : 32901087
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic beta-cells. | Arginine | glucokinase | Homo sapiens |
| 2 | Glucokinase (GCK), the key regulator of GSIS and a disease-causing gene of maturity-onset diabetes of the young type 2 (MODY2), was found to bind L-arginine. | Arginine | glucokinase | Homo sapiens |
| 3 | Glucokinase (GCK), the key regulator of GSIS and a disease-causing gene of maturity-onset diabetes of the young type 2 (MODY2), was found to bind L-arginine. | Arginine | glucokinase | Homo sapiens |
| 4 | Glucokinase (GCK), the key regulator of GSIS and a disease-causing gene of maturity-onset diabetes of the young type 2 (MODY2), was found to bind L-arginine. | Arginine | glucokinase | Homo sapiens |
| 5 | We analyzed glucokinase mutants and identified three glutamate residues that mediate binding to L-arginine. | Arginine | glucokinase | Homo sapiens |
| 6 | One MODY2 patient with GCKE442* demonstrated lower C-peptide-to-glucose ratio after arginine administration. | Arginine | glucokinase | Homo sapiens |
| 7 | In addition, we elucidated that the binding of arginine protects glucokinase from degradation by E3 ubiquitin ligase cereblon mediated ubiquitination. | Arginine | glucokinase | Homo sapiens |
| 8 | We conclude that L-arginine induces insulin secretion by increasing G6P production by glucokinase through direct stimulation and by prevention of degradation. | Arginine | glucokinase | Homo sapiens |