Protein Name glucokinase
Organism Homo sapiens
Gene ID 2645
Gene Symbol


UniProt P35557 (HXK4_HUMAN), Q53Y25 (Q53Y25_HUMAN)
Relationships Total Number of functionally related compound(s) : 300
Total Number of Articles : 662


Gene Summary

This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]

  • hexokinase-4
  • ATP:D-hexose 6-phosphotransferase
  • HK IV
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