Title : Antinociceptive effects of IL-6R vs. glucocorticoid receptors during rat hind paw inflammatory pain.

Pub. Date : 2020 Nov 1

PMID : 32898615






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1 CONCLUSION: The enhanced mechanical sensitivity accompanying the increase of IL-6Ralpha and GR was attenuated by anti-IL-6R and dexamethasone application, and the sub-additive effects were regulated by the decreased activation of neurons and glial cells and modulated by IL-6/JAK2/STAT3 signaling pathway, which might be attributed to IL-6 induced trans-signaling. Dexamethasone Janus kinase 2 Rattus norvegicus