Pub. Date : 2020 Sep 7
PMID : 32893519
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Telmisartan decreased VSMC proliferation, which was accompanied by decreased phosphorylations of mammalian target of rapamycin (mTOR) at Ser2448 (p-mTOR-Ser2448) and p70 S6 kinase (p70S6K) at Thr389 (p-p70S6K-Thr389) in dose- and time-dependent manners. | Telmisartan | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | RESULTS: Telmisartan decreased VSMC proliferation, which was accompanied by decreased phosphorylations of mammalian target of rapamycin (mTOR) at Ser2448 (p-mTOR-Ser2448) and p70 S6 kinase (p70S6K) at Thr389 (p-p70S6K-Thr389) in dose- and time-dependent manners. | Telmisartan | ribosomal protein S6 kinase B1 | Homo sapiens |
| 3 | RESULTS: Telmisartan decreased VSMC proliferation, which was accompanied by decreased phosphorylations of mammalian target of rapamycin (mTOR) at Ser2448 (p-mTOR-Ser2448) and p70 S6 kinase (p70S6K) at Thr389 (p-p70S6K-Thr389) in dose- and time-dependent manners. | Telmisartan | ribosomal protein S6 kinase B1 | Homo sapiens |
| 4 | Co-treatment with compound C, a specific AMPK inhibitor, or ectopic expression of the dn-AMPKalpha1 gene, significantly reversed telmisartan-inhibited VSMC proliferation, p-mTOR-Ser2448 and p-p70S6K-Thr389 levels. | Telmisartan | ribosomal protein S6 kinase B1 | Homo sapiens |
| 5 | Among the ARBs tested (including losartan and fimasartan), only telmisartan increased p-AMPK-Thr172 and decreased p-mTOR-Ser2448, p-p70S6K-Thr389, and VSMC proliferation. | Telmisartan | ribosomal protein S6 kinase B1 | Homo sapiens |
| 6 | CONCLUSION: These results demonstrated that telmisartan-activated AMPK inhibited basal and PDGF-stimulated VSMC proliferation, at least in part, by downregulating the mTOR/p70S6K signaling axis in a PPARgamma-independent manner. | Telmisartan | ribosomal protein S6 kinase B1 | Homo sapiens |