Title : Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy.

Pub. Date : 2020 Sep 3

PMID : 32883957






1 Functional Relationships(s)
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1 Both the pharmacological inhibition of Cdk5 by roscovitine and the inhibition of Drp1 by mdivi-1 inhibited mitochondrial fission and the production of ROS associated with radiation-induced neuronal loss. Roscovitine cyclin dependent kinase 5 Homo sapiens