Title : Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.

Pub. Date : 2020 Oct

PMID : 32871086






1 Functional Relationships(s)
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1 RESULTS: Melatonin improved the total antioxidant capacity (T-AOC) of the HK-2 cells, as evidenced by the dose-dependent reduction in apoptosis, ROS levels, and protein expression of ATF6, GRP78, DDIT3, p-PERK, p-IRE1, XBP1s, caspase-12, cleaved caspase-3 and cleaved caspase-9. Melatonin endoplasmic reticulum to nucleus signaling 1 Homo sapiens