Pub. Date : 2020 Sep
PMID : 32863226
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Specific O-GlcNAc modification at Ser-615 modulates eNOS function. | Serine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 2 | We recently demonstrated that glucose dysregulation results in augmented protein serine/threonine hydroxyl-linked N-Acetyl-glucosamine (O-GlcNAc) modification in IPAH. | Serine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 3 | Here we show that increased protein O-GlcNAc occurs on eNOS in PAH and Ser-615 appears to be a novel site of O-GlcNAc modification resulting in reduced eNOS dimerization. | Serine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 4 | Here we show that increased protein O-GlcNAc occurs on eNOS in PAH and Ser-615 appears to be a novel site of O-GlcNAc modification resulting in reduced eNOS dimerization. | Serine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |
| 5 | Here we demonstrate a previously unidentified regulatory mechanism of eNOS whereby the O-GlcNAc modification of Ser-615 results in reduced eNOS activity and endothelial dysfunction under conditions of glucose dysregulation. | Serine | O-linked N-acetylglucosamine (GlcNAc) transferase | Homo sapiens |