Title : KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.

Pub. Date : 2020 Aug 27

PMID : 32854746






2 Functional Relationships(s)
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1 KIAA1522 potentiates the TNFalpha-TNFR2-NFkappaB signaling which in turn intensifies recalcitrance to cisplatin treatment. Cisplatin tumor necrosis factor Mus musculus
2 These results were further manifested by integrative bioinformatic analyses of independent datasets, in which KIAA1522 is tightly associated with the activity of TNFalpha-NFkappaB pathway and the cisplatin-resistant gene signatures. Cisplatin tumor necrosis factor Mus musculus