Title : The multi-targets mechanism of hydroxychloroquine in the treatment of systemic lupus erythematosus based on network pharmacology.

Pub. Date : 2020 Nov

PMID : 32854577






1 Functional Relationships(s)
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1 RESULTS: The results suggest that the efficacy of HCQ against SLE is mainly associated with the targets of cyclin-dependent kinase 2 (CDK2), estrogen receptor alpha (ESR1) and CDK1, which regulate PI3K/Akt/GSK3beta as well as interferon (IFN) signaling pathway. Hydroxychloroquine AKT serine/threonine kinase 1 Homo sapiens