Pub. Date : 2020
PMID : 32850387
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sildenafil, a specific phosphodiesterase type 5 (PDE5) inhibitor, has been suggested to display both cardioprotective and neuroprotective activities that provide a rationale for the combination with vincristine on the treatment against castration-resistant prostate cancer (CRPC). | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 2 | Sildenafil, a specific phosphodiesterase type 5 (PDE5) inhibitor, has been suggested to display both cardioprotective and neuroprotective activities that provide a rationale for the combination with vincristine on the treatment against castration-resistant prostate cancer (CRPC). | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 3 | Sildenafil-mediated synergistic effects were mimicked by other PDE5 inhibitors including vardenafil and tadalafil, and also by PDE5A knockdown in cells, suggesting PDE5-involved mechanism. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 4 | Sildenafil-mediated synergistic effects were mimicked by other PDE5 inhibitors including vardenafil and tadalafil, and also by PDE5A knockdown in cells, suggesting PDE5-involved mechanism. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 5 | Sildenafil-mediated synergistic effects were mimicked by other PDE5 inhibitors including vardenafil and tadalafil, and also by PDE5A knockdown in cells, suggesting PDE5-involved mechanism. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 6 | In conclusion, the data suggest that sildenafil, in a PDE5-dependent manner, potentiates vincristine-induced mitotic arrest signaling, and sensitizes mitochondria damage-involved apoptosis in CRPC. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |