Pub. Date : 2020
PMID : 32849848
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Beyond Single Nucleotide Polymorphisms: CYP3A5*3*6*7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A5 (CYP3A5) isoenzymes and membrane transport by P-glycoprotein. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Tacrolimus pharmacokinetics was investigated in 65 stable Black and Caucasian post-renal transplant patients by assessing the effects of multiple alleles in both CYP3A5 and ABCB1. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Finally, a combined analysis using both CYP3A5 and ABCB1 polymorphisms was developed to assess their inter-related influence on tacrolimus pharmacokinetics. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The ABCB1 haplotype analysis detected significant associations of the wildtype 1236T-2677T-3435T haplotype to tacrolimus dose (P = 0.03), CL (P = 0.023), CL/LBW (P = 0.022), and AUC* (P = 0.078). | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Finally, analysis combining CYP3A5 and ABCB1 genotypes indicated that the presence of the ABCB1 3435 T allele significantly reduced tacrolimus clearance for all three CPY3A5 metabolic composite groups. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Finally, analysis combining CYP3A5 and ABCB1 genotypes indicated that the presence of the ABCB1 3435 T allele significantly reduced tacrolimus clearance for all three CPY3A5 metabolic composite groups. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | Genotypic associations of tacrolimus pharmacokinetics can be improved by using the novel composite CYP3A5*3*4*5 and ABCB1 haplotypes. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | Consideration of multiple alleles using CYP3A5 metabolic composites and drug transporter ABCB1 haplotypes provides a more comprehensive appraisal of genetic factors contributing to interpatient variability in tacrolimus pharmacokinetics among Whites and Blacks. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |