Title : Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.

Pub. Date : 2020

PMID : 32848753






3 Functional Relationships(s)
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1 Moreover, our study found that TMZ upregulated Sirt1 expression by increasing the expression of nicotinamide phosphoribosyl transferase (Nampt), which is a rate limiting enzyme for nicotinamide adenine dinucleotide (NAD+) generation by salvage pathway. NAD sirtuin 1 Rattus norvegicus
2 Moreover, our study found that TMZ upregulated Sirt1 expression by increasing the expression of nicotinamide phosphoribosyl transferase (Nampt), which is a rate limiting enzyme for nicotinamide adenine dinucleotide (NAD+) generation by salvage pathway. NAD sirtuin 1 Rattus norvegicus
3 And the increased NAD+ promoted Sirt1 expression. NAD sirtuin 1 Rattus norvegicus