Pub. Date : 2020
PMID : 32831633
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Moreover, inhibition of the ROS-EGFR pathway with Nox1/4 inhibitor GKT137831 or selective EGFR inhibitor AG1478 reduced protein and mRNA levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta), as well as the activities of Akt and extracellular signal-regulated kinase (ERK) 1/2 in the left ventricle of SHRs. | Reactive Oxygen Species | tumor necrosis factor | Rattus norvegicus |
2 | Moreover, inhibition of the ROS-EGFR pathway with Nox1/4 inhibitor GKT137831 or selective EGFR inhibitor AG1478 reduced protein and mRNA levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta), as well as the activities of Akt and extracellular signal-regulated kinase (ERK) 1/2 in the left ventricle of SHRs. | Reactive Oxygen Species | tumor necrosis factor | Rattus norvegicus |