Title : Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and ERK1/2.

Pub. Date : 2020

PMID : 32831633






2 Functional Relationships(s)
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1 Moreover, inhibition of the ROS-EGFR pathway with Nox1/4 inhibitor GKT137831 or selective EGFR inhibitor AG1478 reduced protein and mRNA levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta), as well as the activities of Akt and extracellular signal-regulated kinase (ERK) 1/2 in the left ventricle of SHRs. Reactive Oxygen Species tumor necrosis factor Rattus norvegicus
2 Moreover, inhibition of the ROS-EGFR pathway with Nox1/4 inhibitor GKT137831 or selective EGFR inhibitor AG1478 reduced protein and mRNA levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta), as well as the activities of Akt and extracellular signal-regulated kinase (ERK) 1/2 in the left ventricle of SHRs. Reactive Oxygen Species tumor necrosis factor Rattus norvegicus