Title : Glucose induces metabolic reprogramming in neutrophils during type 2 diabetes to form constitutive extracellular traps and decreased responsiveness to lipopolysaccharides.

Pub. Date : 2020 Dec 1

PMID : 32827651






4 Functional Relationships(s)
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Protein Name
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1 We show that glucose induces NADPH oxidase derived reactive oxygen species and further citrullinates the histones to form weaker NETs leading to reduced response to lipopolysaccharide (LPS). Glucose 2,4-dienoyl-CoA reductase 1 Homo sapiens
2 NADPH is an absolute requirement for three independent pathways of formation of 1-anhydrosorbitol via aldose reductase under excess glucose, induction of glutathione synthesis and glucose induced NETs formation. Glucose 2,4-dienoyl-CoA reductase 1 Homo sapiens
3 NADPH is an absolute requirement for three independent pathways of formation of 1-anhydrosorbitol via aldose reductase under excess glucose, induction of glutathione synthesis and glucose induced NETs formation. Glucose 2,4-dienoyl-CoA reductase 1 Homo sapiens
4 During T2D and in presence of high glucose, there is a competition for NADPH between these processive reactions, which leads to its insufficiency to produce NETs in response to LPS. Glucose 2,4-dienoyl-CoA reductase 1 Homo sapiens