PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32827651-5 2020 We show that glucose induces NADPH oxidase derived reactive oxygen species and further citrullinates the histones to form weaker NETs leading to reduced response to lipopolysaccharide (LPS). Glucose 13-20 2,4-dienoyl-CoA reductase 1 Homo sapiens 29-34 32827651-7 2020 NADPH is an absolute requirement for three independent pathways of formation of 1-anhydrosorbitol via aldose reductase under excess glucose, induction of glutathione synthesis and glucose induced NETs formation. Glucose 132-139 2,4-dienoyl-CoA reductase 1 Homo sapiens 0-5 32827651-7 2020 NADPH is an absolute requirement for three independent pathways of formation of 1-anhydrosorbitol via aldose reductase under excess glucose, induction of glutathione synthesis and glucose induced NETs formation. Glucose 180-187 2,4-dienoyl-CoA reductase 1 Homo sapiens 0-5 32827651-8 2020 During T2D and in presence of high glucose, there is a competition for NADPH between these processive reactions, which leads to its insufficiency to produce NETs in response to LPS. Glucose 35-42 2,4-dienoyl-CoA reductase 1 Homo sapiens 71-76