Pub. Date : 2020 Dec
PMID : 32826232
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Folate Cycle Enzyme MTHFR is a Critical Regulator of Cell Response to MYC-Targeting Therapies. | Folic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Here, we identify amino acid-related pathways connected to the folate cycle whose activation predicts sensitivity to MYC-targeting therapies in acute myeloid leukemia (AML). | Folic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML. | Folic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML. | Folic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | Our data provide a rationale for screening MTHFR polymorphisms and the folate cycle status to nominate patients most likely to benefit from MYC-targeting therapies. | Folic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |