Title : Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players.

Pub. Date : 2020 Aug 13

PMID : 32823594






5 Functional Relationships(s)
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1 Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players. Caffeine cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (-163C > A, rs762551; characterized such as "fast" (AA genotype) and "slow" caffeine metabolizers (C-carriers)) and ADORA2A (1976T > C; rs5751876; characterized by "high" (TT genotype) or "low" sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players. Caffeine cytochrome P450 family 1 subfamily A member 2 Homo sapiens
3 The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (-163C > A, rs762551; characterized such as "fast" (AA genotype) and "slow" caffeine metabolizers (C-carriers)) and ADORA2A (1976T > C; rs5751876; characterized by "high" (TT genotype) or "low" sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players. Caffeine cytochrome P450 family 1 subfamily A member 2 Homo sapiens
4 The aim of this study is to analyze the influence of the genetic variations in CYP1A2 (-163C > A, rs762551; characterized such as "fast" (AA genotype) and "slow" caffeine metabolizers (C-carriers)) and ADORA2A (1976T > C; rs5751876; characterized by "high" (TT genotype) or "low" sensitivity to caffeine (C-carriers)) on the ergogenic response to acute caffeine intake in professional handball players. Caffeine cytochrome P450 family 1 subfamily A member 2 Homo sapiens
5 There was only a genotype x treatment interaction for the ball throwing from 7 m (p = 0.037) indicating that the ergogenic effect of caffeine on this test was higher in CYP1A2 AA homozygotes than in C-allele carriers. Caffeine cytochrome P450 family 1 subfamily A member 2 Homo sapiens