Title : Low-molecular mimetics of nerve growth factor and brain-derived neurotrophic factor: Design and pharmacological properties.

Pub. Date : 2021 Sep

PMID : 32808322






1 Functional Relationships(s)
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1 Special attention is paid to the dipeptide mimetics of individual NGF and BDNF loops having different patterns of activation of Trk receptors signal transduction pathways, phosphoinositide 3-kinase/protein kinase B and mitogen-activated protein kinase/extracellular signal-regulated kinase, which allowed to evaluate the contribution of each pathway to different pharmacological effects. Dipeptides neurotrophic receptor tyrosine kinase 1 Homo sapiens