Protein Name neurotrophic receptor tyrosine kinase 1
Organism Homo sapiens
Gene ID 4914
Gene Symbol


UniProt P04629 (NTRK1_HUMAN), X5DR71 (X5DR71_HUMAN)
Relationships Total Number of functionally related compound(s) : 401
Total Number of Articles : 648

neurotrophic receptor tyrosine kinase 1

Gene Summary

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

  • high affinity nerve growth factor receptor
  • Oncogene TRK
  • TRK1-transforming tyrosine kinase protein
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