Title : Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance.

Pub. Date : 2020 Aug 15

PMID : 32801295






1 Functional Relationships(s)
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1 We identified the molecular mechanism by which RMS cells acquire resistance to vincristine: an enhanced binding of BID and BAK to MCL-1 after drug exposure, which is suppressed by subsequently adding S63845. S63845 BH3 interacting domain death agonist Homo sapiens