Pub. Date : 2020 Oct 20
PMID : 32800552
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vandetanib inhibits cell growth in EGFR-expressing cutaneous squamous cell carcinoma. | vandetanib | epidermal growth factor receptor | Homo sapiens |
| 2 | Vandetanib is a multiple tyrosine kinase targeting vascular endothelial growth factor receptor-2 (VEGFR2), EGFR, and the rearranged during transfection (RET) proto-oncogene. | vandetanib | epidermal growth factor receptor | Homo sapiens |
| 3 | Mechanistically, vandetanib suppresses the phosphorylation of EGFR in SCC cells. | vandetanib | epidermal growth factor receptor | Homo sapiens |
| 4 | In conclusion, we identified vandetanib as a novel therapeutic option for cutaneous SCC, especially in tumors with high EGFR expression. | vandetanib | epidermal growth factor receptor | Homo sapiens |