Title : Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinib.

Pub. Date : 2020 Aug 14

PMID : 32795383






1 Functional Relationships(s)
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1 METHODS: To investigate a potential protective effect of adipocyte-conditioned medium on HER2 positive breast cancer cells exposed to tyrosine kinase inhibitors (TKI) such as lapatinib, we analyzed the sensitivity of HER2 positive breast cancer models in vitro and in vivo on SCID mice in the presence or absence of adipocytes or adipocyte-conditioned medium. Lapatinib erb-b2 receptor tyrosine kinase 2 Mus musculus