Pub. Date : 2020 Aug 24
PMID : 32786510
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GDP Release from the Open Conformation of Galpha Requires Allosteric Signaling from the Agonist-Bound Human beta2 Adrenergic Receptor. | Guanosine Diphosphate | succinate-CoA ligase GDP/ADP-forming subunit alpha | Homo sapiens |
| 2 | Interestingly, while GDP remained bound with the Galpha-protein for the two inactive systems (antagonist-bound and apo form), GDP dissociated from the open conformation of the Galpha protein for the agonist activated system. | Guanosine Diphosphate | succinate-CoA ligase GDP/ADP-forming subunit alpha | Homo sapiens |
| 3 | Interestingly, while GDP remained bound with the Galpha-protein for the two inactive systems (antagonist-bound and apo form), GDP dissociated from the open conformation of the Galpha protein for the agonist activated system. | Guanosine Diphosphate | succinate-CoA ligase GDP/ADP-forming subunit alpha | Homo sapiens |
| 4 | Based on residue interaction network analysis, we observed that engagement of agonist-bound beta2AR with an alpha5 helix of Galpha is essential for the GDP release and the residues in the phosphate-binding loop, alpha1 helix, and alpha5 helix play very important roles in the GDP release. | Guanosine Diphosphate | succinate-CoA ligase GDP/ADP-forming subunit alpha | Homo sapiens |
| 5 | Based on residue interaction network analysis, we observed that engagement of agonist-bound beta2AR with an alpha5 helix of Galpha is essential for the GDP release and the residues in the phosphate-binding loop, alpha1 helix, and alpha5 helix play very important roles in the GDP release. | Guanosine Diphosphate | succinate-CoA ligase GDP/ADP-forming subunit alpha | Homo sapiens |