Title : ERK-mediated negative feedback regulation of oncogenic EGFRvIII in glioblastoma cells.

Pub. Date : 2020 Sep

PMID : 32782566






1 Functional Relationships(s)
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1 The present study indicated that activation of the MEK-ERK pathway led to the phosphorylation of Thr-402, a conserved negative feedback residue in the juxtamembrane domain corresponding to Thr-669 of wild-type EGFR (EGFRwt), which resulted in a rapid reduction in the tyrosine phosphorylation of EGFRvIII in U87MG human glioblastoma and 293 cells. Tyrosine mitogen-activated protein kinase 1 Homo sapiens