Title : Celastrol alleviates metabolic disturbance in high-fat diet-induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation.

Pub. Date : 2021 Jan

PMID : 32776627






1 Functional Relationships(s)
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1 Further studies found that celastrol decreased the infiltration of macrophage as well as its inflammatory products (IL-1beta, IL-18, MCP-1alpha, and TNF-alpha) in liver and adipose tissues, which also displayed an obvious inhibition of TLR3/NLRP3 inflammasome molecules. celastrol NLR family, pyrin domain containing 3 Mus musculus