Pub. Date : 2020 Oct 1
PMID : 32771556
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results demonstrated that 3beta-hydroxycholest-5-en-7-one exerted an anti-inflammatory effect via miR-98-5p, which negatively regulated the expression of its target gene TNFAIP3. | 7-ketocholesterol | tumor necrosis factor, alpha-induced protein 3 | Mus musculus |
| 2 | The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion. | 7-ketocholesterol | tumor necrosis factor, alpha-induced protein 3 | Mus musculus |
| 3 | SIGNIFICANCE: 3beta-Hydroxycholest-5-en-7-one alleviates inflammation by downregulating miR-98-5p and upregulating TNFAIP3, thereby blocking NF-kappaB pathway activation. | 7-ketocholesterol | tumor necrosis factor, alpha-induced protein 3 | Mus musculus |