Title : Co-administration of Wuzhi tablet (Schisandra sphenanthera extract) alters tacrolimus pharmacokinetics in a dose- and time-dependent manner in rats.

Pub. Date : 2020 Dec 5

PMID : 32768638






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 However, WZ possesses a biphasic effect on regulating CYP3A (the major metabolizing enzyme of tacrolimus), which could induce the mRNA and protein expression after long-term treatment while transiently inhibit the activity of CYP3A. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 However, WZ possesses a biphasic effect on regulating CYP3A (the major metabolizing enzyme of tacrolimus), which could induce the mRNA and protein expression after long-term treatment while transiently inhibit the activity of CYP3A. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens