Title : PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination.

Pub. Date : 2020 Aug

PMID : 32747411






1 Functional Relationships(s)
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Protein Name
Organism
1 The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119Ub1) through a multi-protein core comprised of BAP1, HCFC1, FOXK1/2, and OGT in combination with either of ASXL1, 2 or 3. Lysine O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens