Pub. Date : 2021 Aug
PMID : 32746697
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, the in vivo physiological functions of the iron metabolism-related gene Hfe in immune response during viral infection remain poorly understood. | Iron | homeostatic iron regulator | Homo sapiens |
| 2 | Here, we identified 5 iron metabolism-associated genes specifically affected during RNA virus infection by a high-throughput assay and further found that HFE was a key negative regulator of RIG-I-like receptors (RLR)-mediated type I interferons (IFNs) signaling. | Iron | homeostatic iron regulator | Homo sapiens |
| 3 | These findings established a novel regulatory role of selective autophagy in innate antiviral immune response by the iron metabolism-related gene Hfe. | Iron | homeostatic iron regulator | Homo sapiens |