Protein Name homeostatic iron regulator
Organism Homo sapiens
Gene ID 3077
Gene Symbol


UniProt Q30201 (HFE_HUMAN), F8W7W8 (F8W7W8_HUMAN), B4DV50 (B4DV50_HUMAN)
Relationships Total Number of functionally related compound(s) : 167
Total Number of Articles : 984

homeostatic iron regulator

Gene Summary

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. [provided by RefSeq, May 2022]

  • hereditary hemochromatosis protein
  • MHC class I-like protein HFE
  • hereditary hemochromatosis protein HLA-H
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