Title : Elevated estrogen receptor β expression in triple negative breast cancer cells is associated with sensitivity to doxorubicin by inhibiting the PI3K/AKT/mTOR signaling pathway.

Pub. Date : 2020 Aug

PMID : 32742395






3 Functional Relationships(s)
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1 Elevated estrogen receptor beta expression in triple negative breast cancer cells is associated with sensitivity to doxorubicin by inhibiting the PI3K/AKT/mTOR signaling pathway. Doxorubicin mechanistic target of rapamycin kinase Homo sapiens
2 Moreover, the synergistic effect of Liq and DOX treatment was associated with the inhibition of the PI3K/AKT/mTOR signaling pathway in MDA-MB-231 cells, and the effect was ERbeta-dependent. Doxorubicin mechanistic target of rapamycin kinase Homo sapiens
3 The results suggested that elevated ERbeta expression was associated with sensitivity to doxorubicin by inhibiting the PI3K/AKT/mTOR signaling pathway; therefore, the combined use of conventional chemotherapeutic drugs with ERbeta agonists may serve as an effective therapy for TNBC. Doxorubicin mechanistic target of rapamycin kinase Homo sapiens