Pub. Date : 2020 Aug
PMID : 32742395
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Elevated estrogen receptor beta expression in triple negative breast cancer cells is associated with sensitivity to doxorubicin by inhibiting the PI3K/AKT/mTOR signaling pathway. | Doxorubicin | mechanistic target of rapamycin kinase | Homo sapiens |
2 | Moreover, the synergistic effect of Liq and DOX treatment was associated with the inhibition of the PI3K/AKT/mTOR signaling pathway in MDA-MB-231 cells, and the effect was ERbeta-dependent. | Doxorubicin | mechanistic target of rapamycin kinase | Homo sapiens |
3 | The results suggested that elevated ERbeta expression was associated with sensitivity to doxorubicin by inhibiting the PI3K/AKT/mTOR signaling pathway; therefore, the combined use of conventional chemotherapeutic drugs with ERbeta agonists may serve as an effective therapy for TNBC. | Doxorubicin | mechanistic target of rapamycin kinase | Homo sapiens |