Pub. Date : 2020 Sep 25
PMID : 32738202
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the present study was to investigate the effects of acacetin on the activities of the cytochrome P450 family members CYP1A2, CYP2B1, CYP2C11, CYP2D1, CYP2E1, and CYP3A2 in rat liver microsomes in vitro and rats in vivo to evaluate potential herb-drug interactions by using a cocktail approach. | acacetin | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | In vitro, the mode of acacetin inhibition of CYP2B1, CYP2C11, and CYP2E1 was competitive, while mixed inhibition was observed for CYP1A2 and CYP3A2. | acacetin | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |