Title : Drug-drug and drug-food interactions in an infant with early-onset SCN2A epilepsy treated with carbamazepine, phenytoin and a ketogenic diet.

Pub. Date : 2021 Mar

PMID : 32737897






1 Functional Relationships(s)
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1 Model-based analysis of carbamazepine-pharmacokinetics quantified significant time- and dose-dependent phenytoin-mediated CYP3A4 induction and carbamazepine-concentration-dependent auto-induction (apparent clearance increased up to 2.5/3-fold). Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens