Title : Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer.

Pub. Date : 2020

PMID : 32724460






1 Functional Relationships(s)
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1 RESULTS: We found that highly potent and specific Mcl-1 inhibitors such as S63845 overcame regorafenib resistance by restoring apoptosis in multiple regorafenib-resistant CRC models. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens