Pub. Date : 2020
PMID : 32714135
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potent Natural Antioxidant Carveol Attenuates MCAO-Stress Induced Oxidative, Neurodegeneration by Regulating the Nrf-2 Pathway. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | Carveol significantly reversed the oxidative stress and downregulated inflammatory cascades by enhancing endogenous antioxidant mechanisms including the Nrf2 gene, which critically regulates the expression of several downstream antioxidants. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | Together, our findings suggest that carveol could activate endogenous master anti-oxidant Nrf2, which further regulates the expression of downstream antioxidants, eventually ameliorating MCAO-induced neuroinflammation and neurodegeneration. | carveol | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |