Pub. Date : 2020 Sep
PMID : 32705282
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine alleviates LPS-induced acute lung injury via regulation of the p38/HO-1 pathway. | Dexmedetomidine | mitogen activated protein kinase 14 | Rattus norvegicus |
| 2 | It was demonstrated that Dex administration significantly alleviated LPS-induced ALI, downregulated the secretion of IL-1beta, decreased the expression of NLRP3, inhibited the phospho-activation of p38 and increased HO-1 expression. | Dexmedetomidine | mitogen activated protein kinase 14 | Rattus norvegicus |
| 3 | In addition, pharmacological inhibition of p38 using the inhibitor SB20380 further enhanced the effect of Dex. | Dexmedetomidine | mitogen activated protein kinase 14 | Rattus norvegicus |
| 4 | Collectively, these preliminarily results identified the effects of Dex intervention on the pathogenesis of ALI via the regulation of p38/HO-1 signaling pathways, which impacted the inflammatory effects, thus providing a theoretical basis and novel evidence for the development of new targets for clinical treatment of ALI. | Dexmedetomidine | mitogen activated protein kinase 14 | Rattus norvegicus |