Title : Autocrine C-peptide protects INS1 β cells against palmitic acid-induced oxidative stress in peroxisomes by inducing catalase.

Pub. Date : 2020 Jul

PMID : 32704568






3 Functional Relationships(s)
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1 Aims: C-peptide, produced by pancreatic beta cells and co-secreted in the bloodstream with insulin, has antioxidant properties in glucose- and hydrogen peroxide (H2O2)-exposed INS1 beta cells. Glucose insulin 2 Rattus norvegicus
2 Materials and methods: We exposed INS1 beta cells to palmitic acid and C-peptide in the setting of increasing glucose concentration and tested for changes in parameters of stress and death. Glucose insulin 2 Rattus norvegicus
3 Results: C-peptide protects INS1 beta cells from the combined effect of palmitic acid and glucose by reducing peroxisomal H2O2 to baseline levels and increasing expression of catalase. Glucose insulin 2 Rattus norvegicus