Title : Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis.

Pub. Date : 2021 Jan

PMID : 32704090






1 Functional Relationships(s)
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1 We found that urolithin A-lowered mitochondrial calcium influx significantly alleviated high glucose-induced mtROS accumulation and expression of amyloid beta (Abeta)-producing enzymes, such as amyloid precursor protein (APP) and beta-secretase-1 (BACE1), as well as Abeta production. Calcium amyloid beta precursor protein Homo sapiens