Title : Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19.

Pub. Date : 2020 Nov 6

PMID : 32692185






1 Functional Relationships(s)
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1 Here, we used polymerase extension experiments to demonstrate that the active triphosphate form of Sofosbuvir (an FDA-approved hepatitis C drug) is incorporated by SARS-CoV-2 RdRp and blocks further incorporation. Sofosbuvir ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2