Title : Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.

Pub. Date : 2020 Sep

PMID : 32687428






1 Functional Relationships(s)
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1 Mechanistically, we showed that hepatic ACOX1 deficiency decreases the total cytosolic acetyl-CoA levels, which leads to reduced acetylation of RPTOR/RAPTOR, a component of MTORC1, which is a key regulator of macroautophagy/autophagy. Acetyl Coenzyme A acyl-Coenzyme A oxidase 1, palmitoyl Mus musculus