Title : Secoisolariciresinol Diglucoside Exerts Anti-Inflammatory and Antiapoptotic Effects through Inhibiting the Akt/IκB/NF-κB Pathway on Human Umbilical Vein Endothelial Cells.

Pub. Date : 2020

PMID : 32684834






3 Functional Relationships(s)
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1 Meanwhile, SDG inhibited the NF-kappaB pathway and downregulated Akt expression in LPS-induced HUVECs. secoisolariciresinol diglucoside nuclear factor kappa B subunit 1 Homo sapiens
2 Our results indicated that SDG relieves LPS-mediated HUVEC injury by inhibiting the NF-kappaB pathway which is partly dependent on the disruption of Akt activation. secoisolariciresinol diglucoside nuclear factor kappa B subunit 1 Homo sapiens
3 Therefore, SDG exerts its cytoprotective effects in the context of LPS-treated HUVECs via regulation of the Akt/IkappaB/NF-kappaB pathway and may be a potential treatment drug for cardiovascular disease. secoisolariciresinol diglucoside nuclear factor kappa B subunit 1 Homo sapiens