Title : Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity.

Pub. Date : 2020 Sep 1

PMID : 32673902






2 Functional Relationships(s)
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1 Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. beclamide 5-hydroxytryptamine receptor 1A Rattus norvegicus
2 A library of novel anilide and benzylamide derivatives of omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkanoic acids as combined 5-HT1A/5-HT7 receptor ligands and phosphodiesterase PDE4B/PDE7A inhibitors was designed using a structure-based drug design approach. beclamide 5-hydroxytryptamine receptor 1A Rattus norvegicus