Title : Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.

Pub. Date : 2020 Oct

PMID : 32673694






2 Functional Relationships(s)
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1 Knockdown or chemical inhibition of CSNK2B and ACSL1 in Caco-2 cells reduced activity of the ATF6-dependent ERSE reporter gene, diminished transcription of the ATF6 target genes HSP90B1 and HSPA5 and reduced NF-kappaB reporter gene activation upon tunicamycin stimulation. Tunicamycin acyl-CoA synthetase long chain family member 1 Homo sapiens
2 Inhibitors of ACSL1 or CSNK2B prevented activation of ATF6 and reduced CXCL1 and TNF expression in these organoids upon induction of ER stress with tunicamycin. Tunicamycin acyl-CoA synthetase long chain family member 1 Homo sapiens