Title : Synthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach.

Pub. Date : 2020 Sep 1

PMID : 32663641






1 Functional Relationships(s)
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1 To develop inhibitors blocking VEGFR2 and the Raf/MEK/ERK mitogen-activated protein kinase signaling pathway new compounds based on sorafenib were designed, synthesized and biologically evaluated. Sorafenib kinase insert domain receptor Homo sapiens