Title : Global PROTAC Toolbox for Degrading BCR-ABL Overcomes Drug-Resistant Mutants and Adverse Effects.

Pub. Date : 2020 Aug 13

PMID : 32657579






1 Functional Relationships(s)
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1 Herein, we systematically designed a set of unique PROTACs by globally targeting all the three binding sites of BCR-ABL, including dasatinib-, ponatinib-, and asciminib-based PROTACs. asciminib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens