Title : Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin-Converting Enzyme 2 Receptor.

Pub. Date : 2020 Jul 7

PMID : 32656452






2 Functional Relationships(s)
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1 In this study, the role of thiol-disulfide balance on the interactions between SARS-CoV/CoV-2 spike proteins and ACE2 was investigated using molecular dynamics simulations. Sulfhydryl Compounds surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 The study revealed that the binding affinity was significantly impaired when all of the disulfide bonds of both ACE2 and SARS-CoV/CoV-2 spike proteins were reduced to thiol groups. Sulfhydryl Compounds surface glycoprotein Severe acute respiratory syndrome coronavirus 2