PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32656452-6 2020 In this study, the role of thiol-disulfide balance on the interactions between SARS-CoV/CoV-2 spike proteins and ACE2 was investigated using molecular dynamics simulations. Sulfhydryl Compounds 27-32 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 94-99 32656452-7 2020 The study revealed that the binding affinity was significantly impaired when all of the disulfide bonds of both ACE2 and SARS-CoV/CoV-2 spike proteins were reduced to thiol groups. Sulfhydryl Compounds 167-172 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 136-141